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While studies in the meta-analysis described above excluded patients with a history of gallstones, clinical outcomes showed that higher doses and longer periods of use with GLP1-RAs have been associated with the greatest risk
doi:10.1016/j.molmed.2017.08.001 8 de Picciotto NE, Gano LB, Johnson LC, et al
This can lead to unwanted side effects of higher estrogen in men, such as fluid retention, breast tissue enlargement (gynecomastia), and decreased testicular size
Given the nuances of Aduhelm clinical benefit, there has been a general uncertainty of consistent clinical benefit among patients
they describe the terrain
These medications require a prescription and professional supervision, as potential side effects might include nausea, diarrhea, constipation, or abdominal discomfort
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